First detail of immune cells' surface

When the body is fighting an invading pathogen, white blood cells--including T cells--must respond. Now researchers have imaged how vital receptors on the surface of T cells bundle together when activated for the first time.

The team used a super-resolution microscope called light-sheet direct stochastic optical reconstruction microscopy (dSTORM), which let the researchers visualize this process in mouse lymph nodes at a resolution of approximately 50 nanometers.

The study published in this weeks Proceedings of the National Academy of Sciences could help scientists better understand how to turn up or down the immune system's activity to treat autoimmune diseases, infections or even cancer.

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